À partir du XIIIe siècle, le tableau clinique de l'anorexie mentale se présente sous la forme de l'anorexie mystique. L'exemple retenu est Catherine de Sienne († 1380). Une approche de psychanalyse socio-historique permet de situer sa démarche par rapport à ses conflits intrapsychiques et aux processus idéologiques de son époque. L'anorexie mystique apparaît comme liée à l'histoire personnelle de chacune dans sa constellation familiale comme à l'essor de la mystique affective féminine. On la trouve souvent marquée par une (...) révolte personnelle contre les stratégies matrimoniales des familles bourgeoises dans les cités marchandes. (shrink)

À partir du XIIIe siècle, le tableau clinique de l'anorexie mentale se présente sous la forme de l'anorexie mystique. L'exemple retenu est Catherine de Sienne († 1380). Une approche de psychanalyse socio-historique permet de situer sa démarche par rapport à ses conflits intrapsychiques et aux processus idéologiques de son époque. L'anorexie mystique apparaît comme liée à l'histoire personnelle de chacune dans sa constellation familiale comme à l'essor de la mystique affective féminine. On la trouve souvent marquée par une (...) révolte personnelle contre les stratégies matrimoniales des familles bourgeoises dans les cités marchandes. (shrink)

A partir de réflexions qui mettent en perspective différentes approches philosophiques, cet ouvrage présente une vision prospective de la philosophie - vision pensée sous l'horizon de la philosophie grecque. La philosophie ne peut, semble t-il, se développer indépendamment de toute référence grecque, c'est-à-dire aussi de ce qui constitue son origine. L'enjeu est de tracer les contours d'une philosophie à venir à partir d'une réflexion sur une contribution possible ou nécessaire de la philosophie grecque. On s'interroge sur le sens, les significations (...) et la pertinence de la philosophie grecque aujourd'hui : y a-t-il une nécessité à revenir aux origines de la philosophie, à son premier moment grec? Quelle serait la nature d'une telle nécessité? En quoi la philosophie grecque pourrait-elle constituer une référence obligée et comment penser cette référence? Y a t-il une actualité de la philosophie grecque? Telles sont les différentes questions auxquelles les auteurs de ce livre ont tenté de répondre. (shrink)

We discuss the latent variables construct, particularly in regard to the following: that latent variables are considered as the sole explanatory factor of a disorder; that pragmatic concerns are ignored; and that the relationship of these variables to biological markers is not addressed. Further, we comment on the relationship between bridge symptoms and causality, and discuss the proposal in relationship to other constructs (endophenotypes, connectionist-inspired networks).

Scientific study of dreams requires the most objective methods to reliably analyze dream content. In this context, artificial intelligence should prove useful for an automatic and non subjective scoring technique. Past research has utilized word search and emotional affiliation methods, to model and automatically match human judges’ scoring of dream report’s negative emotional tone. The current study added word associations to improve the model’s accuracy. Word associations were established using words’ frequency of co-occurrence with their defining words as found in (...) a dictionary and an encyclopedia. It was hypothesized that this addition would facilitate the machine learning model and improve its predictability beyond those of previous models. With a sample of 458 dreams, this model demonstrated an improvement in accuracy from 59% to 63% on the negative emotional tone scale, and for the first time reached an accuracy of 77% on the positive scale. (shrink)

Poly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP‐1 (113 kDa), the founding member, and PARP‐2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding (...) novel PARPs now extends considerably the field of poly(ADP‐ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post‐translational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed. BioEssays 26:882–893, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

How do bioethics gatekeepers located in wealthy nations treat bioethics workers from developing countries? Can the policies of leading international bioethics journals—based on a concern for profit that effectively restricts access for most researchers from developing countries—be ethically justified? We examined these policies focusing on the way they influence the ability of researchers in resource-poor countries to participate in the development of the field of bioethics. Eight of the fourteen leading bioethics journals are published by three transnational publishing houses, all (...) of which are based in wealthy nations. None of these eight journals participates in the Health InterNetwork Access to Research Initiative of the World Health Organization, a program that provides free or very low-cost online access to the major journals by researchers in developing countries. Lack of access to these essential resources makes it extremely difficult, if not impossible, for bioethicists in developing countries to learn from, and engage in, the global bioethics dialogue. Thus, exclusionary practices of leading bioethics journals sustain the hegemony of Western bioethics, raising serious questions about professed aspirations to create a truly “global” bioethics. This phenomenon indicates lack of empathy and moral imagination of bioethicists in developed countries, raises serious questions about the ethics of bioethics, and highlights the urgent need for creative solutions to remedy this social injustice. (shrink)

Who are the gatekeepers in bioethics? Does editorial bias or institutional racism exist in leading bioethics journals? We analyzed the composition of the editorial boards of 14 leading bioethics journals by country. Categorizing these countries according to their Human Development Index (HDI), we discovered that approximately 95 percent of editorial board members are based in (very) high-HDI countries, less than 4 percent are from medium-HDI countries, and fewer than 1.5 percent are from low-HDI countries. Eight out of 14 leading bioethics (...) journals have no editorial board members from a medium- or low-HDI country. Eleven bioethics journals have no board members from low-HDI countries. This severe underrepresentation of bioethics scholars from developing countries on editorial boards suggests that bioethics may be affected by institutional racism, raising significant questions about the ethics of bioethics in a global context. (shrink)

Cet ouvrage prend pour objet les effets de la féminisation massive des activités équestres depuis l’après-guerre, tant au niveau statistique que du point de vue du contenu des pratiques. Le sous-titre choisi établit une certaine ambigüité sur la démarche adoptée : il pose la question d’une « avancée », c’est à dire d’un progrès que constituerait ou non la présence des femmes dans le domaine équestre. « Avancée » (mise ici en doute) pour qui? Pour les femmes? Pour les chevaux? (...) Pour l’activi... (shrink)

Une longue introduction précède les contributions de ces trois philosophes et théologiens à la querelle sur la distinction entre l'être et l'essence qui anima la Faculté de théologie de l'Université de Paris dans les années 1280.

Le bonheur; le bonheur est là, à notre portée. Il suffit de nous y mettre immédiatement! Audacieuse, étonnante, renversante, la philosophie de Robert Misrahi nous embarque. Elle est à lire par gros temps, elle agit comme un remontant. Cette pensée solaire est un élan, une force, un souffle qui nous réveille. Elle ravive la liberté, chante le Désir, célèbre la réflexion, matériaux essentiels à la construction de notre joie et de notre bonheur. Cette introduction à la philosophie misrahienne est une (...) invitation à ce beau voyage. Simple, didactique et pratique, elle donne envie de vagabonder, de sillonner, d'explorer et peu à peu d'aller vers le grand large, vers l'œuvre entière. Elle est destinée à tous. Cher lecteur, hâte-toi, hâte-toi donc d'embarquer pour la joie et le bonheur!"--Page 4 of cover. (shrink)

This paper presents our work on textual inference and situates it within the context of the larger goals of machine reading. The textual inference task is to determine if the meaning of one text can be inferred from the meaning of another and from background knowledge. Our system generates semantic graphs as a representation of the meaning of a text. This paper presents new results for aligning pairs of semantic graphs, and proposes the application of natural logic to derive inference (...) decisions from those aligned pairs. We consider this work as first steps toward a system able to demonstrate broad-coverage text understanding and learning abilities. (shrink)

Second person social cognition cannot be restricted to dyadic interactions between two persons (the and the ). Many instances of social communication are triadic, and involve a third person (the ), which is the object of the interaction. We discuss neuropsychological and brain imaging data showing that triadic interactions involve dedicated brain networks distinct from those of dyadic interactions.

An anthology of writings from Plato and Aristotle, including an introductory essay on the history of ancient Greek philosophy and Greek Glossary.

The most important things in this seminal paper are (a) showing that the first part of the chapter is only setting up the aporia and does not provide the solution; (b) showing that the rest of the chapter provides the material for resolving the aporia; (c) showing that the question is not about how we perceive that we perceive, but how we can distinguish between seeing and hearing—how we are aware that we are seeing rather than hearing; (c) showing that (...) this is reducible to how we are aware that a colour is not a sound, and how we perceive the unity of objects that present themselves under more than one sense-modality. Hence the remainder of De anima 3.2 presents both the materials for the solution (actuality of sense and sensed object are one thing) and the solution (there is a common perceiver who receives the input from several senses and can unite them and also differentiate). De anima 3.2 is not about perceiving that we perceive, nor about reflexive self-awareness. The problems of interpretation and of the unity of the chapter are resolved once we see that the topic is how we can tell the difference between input from different sense modalities, how we distinguish between white things and sweet things, or between seeing and hearing, and how we perceive objects as a unity when they present themselves to separate senses. (shrink)

We identify the ways the policies of leading international bioethics journals limit the participation of researchers working in the resource-constrained settings of low- and middle-income countries in the development of the field of bioethics. Lack of access to essential scholarly resources makes it extremely difficult, if not impossible, for many LMIC bioethicists to learn from, meaningfully engage in, and further contribute to the global bioethics discourse. Underrepresentation of LMIC perspectives in leading journals sustains the hegemony of Western bioethics, limits the (...) presentation of diverse moral visions of life, health, and medicine, and undermines aspirations to create a truly “global” bioethics. Limited attention to this problem indicates a lack of empathy and moral imagination on the part of bioethicists in high-income countries, raises questions about the ethics of bioethics, and highlights the urgent need to find ways to remedy this social injustice. (shrink)

Comment la philosophie de Hegel pourrait-elle encore promettre quelque chose puisqu'elle est apparue, aux yeux des lecteurs contemporains, comme une entreprise d'annulation du temps? Le savoir absolu n'est-il pas le resultat du processus dialectique par lequel l'esprit releve toute temporalite et par la toute surprise, l'evenement se produisant toujours trop tard? D'une absence de pensee de l'avenir dans la philosophie de Hegel decoulerait une absence d'avenir de la philosophie hegelienne elle-meme. C'est contre une telle assertion que le present ouvrage s'inscrit (...) en faux; il se propose pour cela de travailler le concept de plasticite, montrant comment il forme en profondeur, a la fois comme sa structure et comme son rythme, le contenu speculatif. Est plastique ce qui est susceptible de recevoir comme de donner la forme, mais aussi de l'aneantir. Hegel degage ce concept de son sol natal, l'art, pour le rendre a sa veritable origine : le developpement de la subjectivite. Est dit plastique, en effet, le rapport que la subjectivite entretient avec l'accident, avec ce qui arrive. L'auto-determination apparait comme proces de temporalisation au sein duquel la subjectivite, dans l'attitude contrastee d'un voir venir, se donne et par la recoit sa propre forme, anticipant son avenir tout en renoncant a en maitriser l'irruption. La plasticite du concept hegelien de temps est le foyer de resistance clandestin ou se prepare la reponse a l'accusation de vulgarite portee par Heidegger a l'encontre de ce meme concept. (shrink)

Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to explore their reasons for participation and experiences within the study. (...) Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

Les données astronomiques des observatoires trouvent une large application sur terre comme sur mer. Par leur structure et leur périodicité, les revues sont particulièrement adaptées aux remontées de données et échanges de commentaires tant entre savants qu'entre savants et «observateurs». Les observatoires régionaux fédèrent au long du XIXe siècle ce mouvement qui rassemble des professionnels intéressés par les applications de ces observations, puis, sous l'impulsion de personnalités comme Camille Flammarion, un public élargi d'amateurs. Ces lieux d'échanges que sont les revues (...) se retrouvent au XXe siècle sur Internet aussi bien sur les sites institutionnels que sur les forums associatifs. (shrink)

Distincte de la responsabilité managériale et de la responsabilité pénale, la responsabilité financière des gestionnaires publics, qui vise à protéger la régularité de la gestion publique, s’inscrit, en France, dans une longue tradition : le contrôle et la responsabilité sont même indissociablement liés à l’existence même des juridictions financières, dont la Cour des comptes constitue le cœur. Si les fondements philosophiques de cette responsabilité demeurent plus que jamais d’actualité, dans un contexte de perte de confiance des citoyens en l’action publique, (...) les modalités pratiques de l’exigence faite aux gestionnaires publics de « rendre compte », et partant de leur responsabilité individuelle, doivent, pour être justes et efficaces, s’adapter en permanence aux évolutions des modes de gestion : la réforme en profondeur des régimes de responsabilité de droit public financier, annoncée pour 2022, en offre un exemple particulièrement pertinent et actuel. Toutefois, la crédibilité dans la durée du nouveau régime dépendra à la fois de la plasticité des infractions et du développement, en amont, de contrôles de régularité pertinents permettant « d’alimenter » le contentieux financier. (shrink)

Research Ethics, Volume 18, Issue 2, Page 132-150, April 2022. Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to (...) explore their reasons for participation and experiences within the study. Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

Dans cet article, il s’agira de questionner les affordances, autrement dit les « signes actanciels », les « valences » ou le « caractère de demande » d’objets numériques iconotextuels tels que l’échelle temporelle numérique dite ticker. Forme d’architexte, le ticker propose un modèle iconique et langagier qui simultanément incite à l’action tout en limitant ce champ d’action. La diversité d’affordances semble dépendre des potentialités intrinsèques à l’objet mais aussi de l’expérience de l’usager. Plus ce coefficient de diversité augmente, plus (...) la possibilité de dépasser le niveau injonctif de l’affordance augmente. En dépit des affordances prévues par les concepteurs et de leurs intentionnalités, les usagers « détournent » les fonctionnalités d’objets numériques en conservant le design initial mais en modifiant les éléments textuels qui l’accompagnent, créant ainsi une nouvelle catégorie, plus invisible, de produsage. (shrink)